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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
XRN2
All Species:
27.58
Human Site:
S704
Identified Species:
43.33
UniProt:
Q9H0D6
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H0D6
NP_036387.2
950
108582
S704
L
E
L
Y
Q
T
G
S
T
E
P
V
E
V
P
Chimpanzee
Pan troglodytes
XP_514546
950
108522
S704
L
E
L
Y
Q
T
G
S
T
E
P
V
D
V
P
Rhesus Macaque
Macaca mulatta
XP_001094734
961
109718
S715
L
E
L
Y
Q
T
G
S
T
E
P
V
D
V
P
Dog
Lupus familis
XP_534324
950
108331
S704
L
E
L
Y
Q
T
G
S
T
E
P
V
D
V
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9DBR1
951
108669
S704
L
E
L
Y
Q
T
G
S
T
E
P
V
D
V
P
Rat
Rattus norvegicus
NP_001102066
561
63850
L352
V
C
S
P
V
P
M
L
R
D
L
T
Q
N
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505862
950
108030
S704
S
E
L
Y
K
T
S
S
A
E
P
V
D
I
P
Chicken
Gallus gallus
Q5ZIP4
949
108524
N703
V
E
Q
Y
K
S
K
N
T
E
P
V
D
M
P
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VM71
908
103942
D683
K
K
I
S
E
K
D
D
E
S
V
C
K
A
I
Honey Bee
Apis mellifera
XP_392371
860
99367
K643
F
K
I
D
L
N
G
K
K
F
A
W
Q
G
V
Nematode Worm
Caenorhab. elegans
Q9U299
975
110109
S730
Q
Q
V
A
E
S
K
S
D
D
L
V
P
L
D
Sea Urchin
Strong. purpuratus
XP_795068
1073
120270
S693
R
E
L
Y
E
T
N
S
L
E
Q
A
E
P
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FQ03
1020
116807
L729
L
D
N
H
C
R
Q
L
S
A
R
E
R
V
D
Baker's Yeast
Sacchar. cerevisiae
Q02792
1006
115915
Y789
E
R
F
S
K
K
L
Y
S
K
E
N
N
N
N
Red Bread Mold
Neurospora crassa
Q8WZX5
1072
118291
K775
T
S
Q
F
Y
S
K
K
Q
G
T
T
K
F
E
Conservation
Percent
Protein Identity:
100
99.7
97.6
98
N.A.
96
56.2
N.A.
91.1
82.9
N.A.
N.A.
N.A.
51.2
54
50.5
52.5
Protein Similarity:
100
99.8
98
99
N.A.
97
57.6
N.A.
95.4
90.5
N.A.
N.A.
N.A.
63.2
66.5
63.7
63.4
P-Site Identity:
100
93.3
93.3
93.3
N.A.
93.3
0
N.A.
60
46.6
N.A.
N.A.
N.A.
0
6.6
13.3
46.6
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
80
86.6
N.A.
N.A.
N.A.
26.6
26.6
53.3
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
42.6
40.5
40.8
Protein Similarity:
N.A.
N.A.
N.A.
58
57.4
56.1
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
0
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
20
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
0
0
0
7
7
7
7
0
7
0
% A
% Cys:
0
7
0
0
7
0
0
0
0
0
0
7
0
0
0
% C
% Asp:
0
7
0
7
0
0
7
7
7
14
0
0
40
0
20
% D
% Glu:
7
54
0
0
20
0
0
0
7
54
7
7
14
0
7
% E
% Phe:
7
0
7
7
0
0
0
0
0
7
0
0
0
7
0
% F
% Gly:
0
0
0
0
0
0
40
0
0
7
0
0
0
7
0
% G
% His:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
14
0
0
0
0
0
0
0
0
0
0
7
7
% I
% Lys:
7
14
0
0
20
14
20
14
7
7
0
0
14
0
0
% K
% Leu:
40
0
47
0
7
0
7
14
7
0
14
0
0
7
0
% L
% Met:
0
0
0
0
0
0
7
0
0
0
0
0
0
7
0
% M
% Asn:
0
0
7
0
0
7
7
7
0
0
0
7
7
14
7
% N
% Pro:
0
0
0
7
0
7
0
0
0
0
47
0
7
7
47
% P
% Gln:
7
7
14
0
34
0
7
0
7
0
7
0
14
0
0
% Q
% Arg:
7
7
0
0
0
7
0
0
7
0
7
0
7
0
0
% R
% Ser:
7
7
7
14
0
20
7
54
14
7
0
0
0
0
0
% S
% Thr:
7
0
0
0
0
47
0
0
40
0
7
14
0
0
7
% T
% Val:
14
0
7
0
7
0
0
0
0
0
7
54
0
40
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% W
% Tyr:
0
0
0
54
7
0
0
7
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _